- As a component of fertilizer and animal feed, providing a relatively cheap source of fixed nitrogen to promote growth.

- As a raw material for the manufacture of plastics specifically, urea-formaldehyde resin.

- As a raw material for the manufacture of various glues (urea-formaldehyde or urea-melamine-formaldehyde). The latter is waterproof and is used for marine plywood.

- As an alternative to rock salt in the deicing of roadways and runways. It does not promote metal corrosion to the extent that salt does.

- As an additive ingredient in cigarettes, designed to enhance flavor.

- Sometimes used as a browning agent in factory-produced pretzels.

- As an ingredient in some hair conditioners, facial cleansers, bath oils and lotions.

- It is also used as a reactant in some ready-to-use cold compresses for first-aid use, due to the endohermic reaction it creates when mixed with water.